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> Professor Man Lok Andrew CHAN
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Professor CHAN Man Lok Andrew
Personal Information
Position and Department
Professor
,
School of Biomedical Sciences
ORCiD
0000-0001-9923-5464
CUHK Research Outputs
1 of 2
A Novel Probiotic-Based Oral Vaccine against SARS-CoV-2 Omicron Variant B.1.1.529
(
2023
)
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
(
2023
)
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models
(
2023
)
Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src-YAP signalling axis
(
2022
)
Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells
(
2022
)
Functional analysis of the short splicing variant encoded by CHI3L1/YKL-40 in glioblastoma
(
2022
)
Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
(
2022
)
PTEN loss is associated with elevation of cell cycle signature in human glioblastoma transcriptome
(
2022
)
The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma
(
2022
)
A potential crosstalk between YKL-40 and PTEN in amyloid beta induced signalling and biological effects in Alzheimer’s disease
(
2021
)
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
(
2021
)
Tumour-derived substrate-adherent cells promote neuroblastoma survival through secreted trophic factors
(
2021
)
Autism-associated PTEN Missense Mutation Leads to Enhanced Nuclear Localization and Neurite Outgrowth in an Induced Pluripotent Stem Cell Line
(
2020
)
PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior
(
2020
)
Targeted drug discovery for Alzheimer disease: abridged secondary publication
(
2020
)
Adaptive upregulation of carbamoyl phosphate synthetase-1 (CPS-1) in glucose-deprived metastatic lung adenocarcinoma cells
(
2019
)
Complete Disruption of UlK1, FAT10 and CtIP Genes by Homology-Independent Multiallelic Knock-in Yielded Distinct Functional Outcomes
(
2019
)
Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease
(
2019
)
Major brain ganglioside-deficient 5XFAD mice exhibit a reduced level of amyloid depositions, diminished activation of microglia, improved neuronal survival, and intact cognitive abilities
(
2019
)
Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions
(
2019
)
Complete Gene Disruption by CRISPR-Based Multiallelic Knock-In Engages Alternative DNA Cleavage and RNA Splicing to Spare Essential Proteins
(
2018
)
Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma
(
2018
)
Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells
(
2018
)
Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly
(
2018
)
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis
(
2018
)
PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model
(
2018
)
A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase
(
2017
)
Effects of PTEN localization and phosphatase activity on gene expression profiling of glioblastoma cells
(
2017
)
Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer.
(
2017
)
Investigating the Mechanisms of Tumor Suppression Mediated by PTEN PDZ-binding Domain in a Murine Breast Cancer Model
(
2017
)
The regulation of PTEN PDZ-binding domain in beta amyloid-induced memory deficits
(
2017
)
The Role of PTEN PDZ-binding Domain in Beta Amyloid-induced Memory Dysfunctions
(
2017
)
The role of tumor cell heterogeneity in the targeted therapy of ALK-positive neuroblastoma
(
2017
)
Formulation of Chinese Medicines Tackling Dementia and Osteoporosis
(
2016
)
Herbal Tonic to Improve Dementia
(
2016
)
Investigating the Role of PTEN PDZ-Binding Domain in Mouse Mammary Tumorigenesis
(
2016
)
MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes
(
2016
)
PTEN recruitment controls synaptic and cognitive function in Alzheimer's models
(
2016
)
The In Vivo and In Vitro Neuroprotective Effects of Innovative Chinese Medicine Formula against Dementia
(
2016
)
A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
(
2015
)
Mapping SUMOylation Sites of PTEN Tumor Suppressor
(
2015
)
Regulating Subcellular Localization of PTEN Tumor Suppressor by SUMOylation
(
2015
)
R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding
(
2015
)
The Genetic Landscapes of Inflammation-Driven Gastrointestinal Tract Cancers
(
2015
)
The Role of PTEN PDZ-binding Domain in Mammary Gland Tumorigenesis
(
2015
)
An increase in tolerogenic dendritic cell and natural regulatory T cell numbers during experimental autoimmune encephalomyelitis in Rras-/mice results in attenuated disease
(
2014
)
A Potential Inhibitor in Treating Alzhenimer's Disease by Docking the PDZ-2 Binding Pocket
(
2014
)
The Role of PTEN PDZ-binding Domain in Mammary Gland Development and Tumorigenesis
(
2014
)
AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion
(
2013
)
Chapter 5: Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment
(
2013
)
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