Assistant Professor Yuk Wai LEE - CUHK Research Portal - CONVERIS Research Information System

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Professor LEE Yuk Wai

Personal Information

Position and Department

Assistant Professor, Department of Orthopaedics and Traumatology

Phone24716706

Emailwaynelee@cuhk.edu.hk

ORCiD0000-0002-0486-360X

ResearcherIDH-8298-2013

CUHK Research Outputs

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A Pilot Single Cell RNA Sequencing Study Suggested that Conditioned Asymmetric Osteogenic Differentiation through mTOR Pathway in Adolescent Idiopathic Scoliosis (AIS) (2024)

Could Ultrasound Curve Angle (UCA) Measurement Reduce Unnecessary X-Ray Exposure for Screening Scoliosis Among Schoolchildren? – A Study of 509 Skeletally Immature Female Subjects (2024)

Developing a Mouse Model of Structural Scoliosis with Special 3D Printed Thoracic Restrainer to Study the Role of Candidate Genes on Curve Progression and Their Potential as Therapeutic Target (2024)

Early Detection of Progressive Adolescent Idiopathic Scoliosis by Unsupervised Machine Learning Clustered Bone Microarchitecture Phenotype: a 3-Year Prospective Longitudinal Study (2024)

Early prediction of curve progression to surgical threshold in Adolescent Idiopathic Scoliosis with bone microarchitecture phenotyping – a step closer to Precision Medicine (2024)

LBX1 Modulates Muscle Function and Curve Progression in Adolescent Idiopathic Scoliosis (2024)

Online Mindfulness Intervention to Enhance Psychosocial Well-being for Adolescent Idiopathic Scoliosis (AIS) – A Pilot Randomized Single-blinded Controlled Trial (2024)

Role of Sagittal Plane Alignment on the Etiopathogenesis of Frontal Plane Deformity in Idiopathic Scoliosis – a Prospective Longitudinal Study (2024)

Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: A large-scale assessment by ultra-high-resolution micro-computed tomography (2023)

A nanopatterned silk-based composite with sustained release of kartogenin for tissue engineering of articular cartilage superficial zone (2023)

Can we predict curve progression in adolescent idiopathic scoliosis patients with Cobb angles <10°? A pilot study with vertebra vector sequencing by recurrent neural networks (RNN) (2023)

Comparison of plugin and redundant marker sets to analyze gait kinematics between different populations (2023)

Cyp27b1 ablation in skeletal muscle impairs muscle regeneration (2023)

Efficient hepatic differentiation of hydrogel microsphere-encapsulated human pluripotent stem cells for engineering prevascularized liver tissue (2023)

Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field (2023)

Genetic insight into the putative causal proteins and druggable targets of osteoporosis: a large-scale proteome-wide mendelian randomization study (2023)

Handgrip strength assessment at baseline in addition to bone parameters could potentially predict the risk of curve progression in adolescent idiopathic scoliosis (2023)

Is dexamethasone-induced muscle atrophy an alternative model for naturally aged sarcopenia model? (2023)

Low-Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T-Cell Effector Immunity (2023)

Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway (2023)

More Prevalent and Severe Low Bone-Mineral Density in Boys with Severe Adolescent Idiopathic Scoliosis Than Girls: A Retrospective Study of 798 Surgical Patients (2023)

Novel Role Of Lncrna H19 In Osteoarthritis Development Via Modulating Subchondral Bone Remodeling And Osteocyte Responses To Mechanical Stimulation (2023)

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair (2023)

OP-323 A nanopatterned silk-based composite with sustained release of kartogenin for tissue engineering of articular cartilage superficial zone (2023)

Prediction of curve progression and progression to surgical threshold in adolescent idiopathic scoliosis with bone microarchitecture phenotyping by an unsupervised machine learning protocol – a 6-year longitudinal study till skeletal maturity and beyond (2023)

Prediction of Curve Progression in Adolescent Idiopathic Scoliosis with Bone Microarchitecture Phenotyping by an Unsupervised Machine Learning Protocol (2023)

Recent Advances in "Functional Engineering of Articular Cartilage Zones by Polymeric Biomaterials Mediated with Physical, Mechanical, and Biological/Chemical Cues" (2023)

Role of sagittal plane malalignment on the etiopathogenesis of frontal plane deformity in idiopathic scoliosis—a prospective longitudinal study (2023)

Targeting subchondral bone osteocytes by magnet guided anti-H19 delivery for osteoarthritis treatment: a preclinical study (2023)

Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: a large-scale assessment of 300,000 lacunae by ultra-high-resolution micro-computed tomography (2022)

A Novel high-efficiency quantitative control of mitochondrial transfer based on droplet microfluidics and its application on muscle regeneration (2022)

A Novel high-efficiency quantitative control of mitochondrial transfer based on droplet microfluidics and its application on muscle regeneration (2022)

A novel prediction model for curve progression to surgical threshold in adolescent idiopathic scoliosis derived from unsupervised machine learning of bone microarchitecture phenotypes – a 6-year longitudinal study of 323 patients followed till skeletal maturity (2022)

A randomised double-blinded placebo-controlled trial with 6 years of longitudinal follow-up on the effect of 2 years of calcium and vitamin D supplementation on the bone density, bone microarchitectural profiles, and curve progression in 330 girls with adolescent idiopathic scoliosis (AIS) (2022)

Association of Vitamin D Status with Bone Density and Bone Qualities during Peripubertal Period and at Peak Bone Mass in Adolescent Idiopathic Scoliosis: a 6-Year Prospective Cohort Study (2022)

Baseline Vitamin D Insufficiency during Pubertal Growth is Associated with Low Peak Bone Mass in Adolescent Idiopathic Scoliosis:a 6-Year Prospective Cohort Study (2022)

Bioactive Film-Guided Soft–Hard Interface Design Technology for Multi-Tissue Integrative Regeneration (2022)

Bioactive Scaffold Fabricated by 3D Printing for Enhancing Osteoporotic Bone Regeneration (2022)

Biological effect of dysregulated LBX1 on Adolescent Idiopathic Scoliosis through modulating muscle carbohydrate metabolism (2022)

Coupling of Peak Height Velocity with Decreased Bone Density and Bone Qualities in AIS (2022)

Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and Modulates Meningeal Lymphatic Function in Middle Cerebral Artery Occlusion Rats (2022)

Decreased cortical bone density and mechanical strength with associated elevated bone turnover markers at peri-pubertal peak height velocity: a cross-sectional and longitudinal cohort study of 396 girls with adolescent idiopathic scoliosis (2022)

Deep learning based adolescent idiopathic scoliosis patients Cobb angles prediction model (2022)

Emerging role of lncRNAs in osteoarthritis: An updated review (2022)

Fetal muscle extract improves muscle function and performance in aged mice (2022)

High-efficiency quantitative control of mitochondrial transfer based on droplet microfluidics and its application on muscle regeneration (2022)

Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family (2022)

Is extracellular matrix remodeling in skeletal muscle a metabolic memory component in the development of hyperglycemia? (2022)

Low baseline serum 25OHD level is associated with better response of bone qualities to vitamin D supplementation during the peripubertal period in adolescent idiopathic scoliosis (2022)

Mesenchymal Stem Cell Therapy: A New Therapeutic Option For Sarcopenia (2022)

Research Interest

My current research directions can be divided into two areas. First, to investigate the basic biology and clinical application potential of human adult or fetal mesenchymal stem cell (MSC) in bone and cartilage repair. I also explore novel treatment strategies such as MSC secretome, miRNA and biomaterials with MSC tracking and controlled release properties. Second, to study the roles of osteocytes in rare bone disorders. Now, the focus is on the link between osteocytes and Adolescent Idiopathic Scoliosis (AIS) which is associated with low systemic bone mineral density. I am also developing transgenic animal for the investigation between bone and muscle interaction in AIS.

Most Relevant Area

Preclinical and animal studies (Biomedical)

Related Area

Tissue engineering (Biomedical engineering)

Orthopaedics and sports medicine (Surgical and related)