Assistant Professor Kam Tong LEUNG - CUHK Research Portal - CONVERIS Research Information System

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Professor LEUNG Kam Tong

Personal Information

Position and Department

Assistant Professor, Department of Paediatrics

Emailktleung@cuhk.edu.hk

ORCiD0000-0002-7695-2513

ResearcherIDI-8569-2017

CUHK Research Outputs

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CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia. (2024)

Isolation of myeloid-derived suppressor cells (MDSC) from endometriotic mice model and their immunomodulatory functions. (2024)

Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China (2024)

An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis (2023)

Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways (2023)

CD38 is a Functional Partner of CD9 in B-cell Precursor Acute Lymphoblastic Leukemia (2023)

Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia (2023)

Drug Response Profiling of Childhood T-cell Acute Lymphoblastic Leukemia to Inform Functional Precision Medicine (2023)

Epigenetic silencing of CD9 shapes a new mechanism to render differentiation block and immune evasion in pediatric acute myeloid leukemia (2023)

Histone hypoacetylation-driven CD9 repression arrests differentiation and evades immunosurveillance in pediatric acute myeloid leukemia (2023)

Prognostic features of CD9 in childhood acute lymphoblastic leukemia – a retrospective analysis of a nation-wide multicenter study in China (2023)

Single Cell Bioinformatics Uncovers a Novel T Cell Origin in the Tumor Microenvironment (2023)

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma (2023)

The Tetraspanin CD9 Shapes Glucocorticoid Sensitivity in Pediatric B-Precursor Acute Lymphoblastic Leukemia (2023)

The topoisomerase-I inhibitor gimatecan exhibits potent and selective activities against B-cell precursor acute lymphoblastic leukemia with a favorable cardiotoxicity profile (2023)

Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy (2023)

Uncovering Neutrophils as Key Immune Regulators and Translating Their Potential into Next-Generation Anticancer Therapy (2023)

ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia (2022)

CD9 marks Differentiation and Anti-Tumor Immunity in Pediatric Acute Myeloid Leukemia (2022)

Engraftment and Mobilization of Human Hematopoietic Stem/Progenitor Cells Aligns with Dynamic Oscillation of Tetraspanin CD9 (2022)

Integrative Drug and Genomic Profiling Identify Therapeutic Vulnerabilities and Inform Precision Medicine for Pediatric Acute Myeloid Leukemia (2022)

LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression (2022)

Mitochondrial-Targeted Therapy for Doxorubicin-Induced Cardiotoxicity (2022)

Pharmacogenomic profiling of pediatric acute myeloid leukemia to identify therapeutic vulnerabilities and inform functional precision medicine (2022)

R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking (2022)

Remdesivir induces persistent mitochondrial and structural damage in human induced pluripotent stem cell derived
cardiomyocytes (2022)

Remdesivir induces persistent mitochondrial and structural damage in human induced pluripotent stem cell-derived cardiomyocytes (2022)

Serial changes in two immune checkpoint receptors and ligands, Tim-3/Gal-9 and PD-1/PD-L1 in peripheral blood prior to miscarriage: comparison with pregnancies resulting in a live birth (2022)

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain (2022)

Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition (Adv. Sci. 1/2022) (2022)

Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition (2022)

Temporal Control of the WNT Signaling Pathway During Cardiac Differentiation Impacts Upon the Maturation State of Human Pluripotent Stem Cell Derived Cardiomyocytes (2022)

TGF-β signaling networks in the tumor microenvironment (2022)

Therapeutic Mechanisms of CD9 Neutralizing Antibodies in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia (2022)

The Tetraspanin CD9 Shapes Glucocorticoid Sensitivity in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia (2022)

The Topoisomerase-I Inhibitor Gimatecan Potently Suppresses B-cell Precursor Acute Lymphoblastic Leukemia without Concurrent Cardiotoxicity (2022)

AANG: A natural compound formula for overcoming multidrug resistance via synergistic rebalancing the TGF-beta/Smad signalling in hepatocellular carcinoma (2021)

A Prospective Cohort Study of Fecal miR-223 and miR-451a as Noninvasive and Specific Biomarkers for Diagnosis of Necrotizing Enterocolitis in Preterm Infants (2021)

Discovery of a Novel Therapeutic Target for Reactivating the Direct Anticancer Activity of Dendritic Cells by Single-cell RNA-sequencing (2021)

Epigenetic Silencing of CD9 Drives Immune Evasion and Disease Progression in Pediatric Acute Myeloid Leukemia (2021)

Histone hypoacetylation-driven CD9 repression arrests differentiation and evades immunosurveillance in pediatric acute myeloid leukemia (2021)

Integrative drug and genomic profiling identify therapeutic vulnerabilities and inform precision medicine for pediatric acute myeloid leukemia (2021)

Interaction between CD9 and PI3K‑p85 activates the PI3K/AKT signaling pathway in B‑lineage acute lymphoblastic leukemia (2021)

R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling (2021)

Single-Cell RNA-Sequencing Uncovers Smad3 as a Master Regulator for Nl/N2 Polarization of Tumor-Associated Neutrophils in Lung Carcinoma (2021)

STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker (2021)

TGF-beta Signaling: From Tissue Fibrosis to Tumor Microenvironment (2021)

TGF-β1 Signaling: Immune Dynamics of Chronic Kidney Diseases (2021)

The miR-223/nuclear factor I-A Axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis (2021)

USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages (2021)

Research Interest

- Therapeutic antibodies and chimeric antigen receptor T cells for childhood acute leukemia
- Functional genomics of childhood acute leukemia and its application for precision medicine
- Molecular mechanisms of hematopoietic stem cell transplantation

Most Relevant Area

Haematological oncology (Internal medicine related)