tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression
Publication in refereed journal

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其它資訊
摘要tRNA-derived stress-induced RNAs (tiRNAs), important components of tRNA-derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggested to act as transducers or effectors involved in cellular stress responses. tiRNAs facilitate cells to respond to stresses mainly via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules. This review introduces the cellular biogenesis, molecular mechanisms, and biological roles of tiRNAs in stress response and disease regulation. A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.
出版社接受日期14.06.2019
著者En‐Wei Tao, Wing Yin Cheng, Wei‐Lin Li, Jun Yu, Qin‐Yan Gao
期刊名稱Journal of Cellular Physiology
出版年份2020
月份2
日期1
卷號235
期次2
出版社Wiley: 12 months
頁次683 - 690
國際標準期刊號0021-9541
語言美式英語

上次更新時間 2020-20-01 於 08:21