Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population
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The incidence of breast cancer among younger East Asian women has been increasing rapidly over recent decades. This international collaborative study systemically compared the differences in age-specific incidences and pathological characteristics of breast cancer in women between East Asian and predominantly European ancestry.

We excerpted analytic data from six national cancer registries (979,675 cases) and eight hospitals (18,008 cases) in East Asian countries/regions and, for comparisons, from the United States Surveillance, Epidemiology, and End Results (SEER) program database. Linear regression analyses of age-specific incidences of female breast cancer and logistic regression analyses of age-specific pathological characteristics of breast cancer were performed. All statistical tests were two-sided.

Unlike female colorectal cancer, the age-specific incidences of breast cancer among East Asian women aged ≤ 59 years increased disproportionally over recent decades relative to rates in United States contemporaries. For years 2010 - 2014, the estimated age-specific probability of estrogen receptor (ER) positivity increased with age in American patients, whereas that of triple negative breast cancer (TNBC) declined with age. No similar trends were evident in East Asian patients: their probability of ER positivity at age 40-49 years was statistically significantly higher (odd ratio [OR] = 1.50, 95% confidence interval [CI]: 1.36-1.67, P < .001) and of TNBC was statistically significantly lower (OR = 0.79, 95% CI: 0.71-0.88, P < .001), whereas the probability of ER positivity at age 50-59 years was statistically significantly lower (OR = 0.88, 95% CI: 0.828-0.95, P < .001). Subgroup analyses of SEER data showed similarly distinct patterns between East Asian American and white American patients.

Contrasting age-specific incidences and pathological characteristics of breast cancer between East Asian and American women, as well as between East Asian Americans and white Americans, suggests racial differences in the biology.
Acceptance Date06/05/2019
All Author(s) ListLin CH, Yap YS, Lee KH, Im SA, Naito Y, Yeo W, Ueno T, Kwong A, Li H, Huang SM, Leung R, Han W, Tan B, Hu FC, Huang CS, Cheng AL, Lu YS
LanguagesEnglish-United Kingdom
KeywordsFemale Breast Cancer, Asians

Last updated on 2019-03-12 at 02:59