5-HT3 receptors are not involved in conditioned taste aversions induced by 5-hydroxytryptamine, ipecacuanha or cisplatin
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AbstractWe have used the rat to examine the involvement of the 5-HT3 receptor in the mechanism(s) of conditioned taste aversion induced by 5-hydroxytryptamine (5-HT) and selected emetic drugs. 5-HT, ipecacuanha and cisplatin all induced conditioned taste aversion at doses known to induce emesis in other species but the responses were resistant to treatment with the 5-HT3 receptor antagonists ondansetron and granisetron. Further, m-chlorophenylbiguanide, a selective and potent 5-HT3 receptor agonist, failed to induce a conditioned taste aversion. The data provide strong evidence that the 5-HT3 receptor is not involved in conditioned taste aversion mechanisms in the rat. Results are discussed in terms of the usefulness of the rat conditioned taste aversion paradigm to anti-emetic research. (C) 1998 Elsevier Science B.V. All rights reserved.
All Author(s) ListRudd JA, Ngan MP, Wai MK
Journal nameEuropean Journal of Pharmacology
Year1998
Month7
Day10
Volume Number352
Issue Number2-3
PublisherELSEVIER SCIENCE BV
Pages143 - 149
ISSN0014-2999
eISSN1879-0712
LanguagesEnglish-United Kingdom
Keywords(rat); 5-HT3 receptor; conditioned taste aversion
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-25-01 at 03:04